Introduction:
In this blog post and video, we delve into the layers, materials, and steps involved in creating the iconic glucose strip and its application to biosensors in general.
The Fluidics of Glucose Strips:
Glucose strips are renowned for their capillary fill mechanism that allows for the automatic filling of the glucose strip by the patient’s blood. The manufacturing process involves layering materials to produce a functional lab-on-a-chip (LoC) system.
Layers of Significance:
A glucose strip comprises several layers: base layer, spacer layer, and top layer.
Cross-Sectional Analysis:
The working end of the sensor involves electrodes, an enzyme layer, cutout double-sided adhesives forming microfluidic channels capped off with a top layer. An air gap between the electrodes and the top layer forms a microfludic channel and plays a critical role in the capillary fill action.
Workflow Breakdown:
The overall manufacturing workflow of glucose strip manufacturing has several key steps. This includes the creation of an enzyme solution, printing of electrodes onto the base layer, the deposition of the enzyme payer onto the working electrode, the placing of a spacer layer that shapes the microfluidic channel, and the top layer lamination that forms the channel.
Electrochemical Testing:
A unique aspect of the manufacturing process at ZP is the electrochemical testing conducted during the electrode printing phase. This quality control measure ensures the reproducibility of materials entering the workflow, contributing to the reliability of the final product.
Conclusion:
In conclusion, the manufacturing workflow of glucose strips is robust and is the ideal strategy for biosensor manufacturing.